Low Estrogen Levels and Its Effects on Insulin Resistance

Written by Veronica Yoo

Understanding the Connection


Estrogen is a vital hormone in the female body, responsible for regulating various physiological processes, including reproductive health, bone density, and metabolism. One critical aspect of estrogen’s influence is its role in glucose metabolism and insulin sensitivity. When estrogen levels decline, as in menopause or certain medical conditions, it can lead to changes in the body’s ability to regulate blood sugar levels, ultimately contributing to insulin resistance. In this blog, we will delve into the intricate relationship between low estrogen levels and insulin resistance, understanding the underlying mechanisms and potential implications for women’s health.

Understanding Estrogen and Insulin Resistance:

Insulin resistance occurs when the body’s cells become less responsive to the hormone insulin, resulting in reduced glucose uptake from the bloodstream into the cells. As a consequence, the pancreas must produce more insulin to maintain normal blood sugar levels, leading to hyperinsulinemia (high insulin levels). Over time, this condition can progress to type 2 diabetes and other metabolic disorders.

Estrogen plays a crucial role in maintaining metabolic homeostasis, and its decline can lead to several changes that impact insulin sensitivity. It influences glucose and lipid metabolism, adipose tissue function, and inflammatory pathways, all of which play a role in the development of insulin resistance.

  1. Adipose Tissue Function:

Estrogen helps regulate the function of adipose tissue, commonly known as body fat. During periods of low estrogen, such as during menopause, there can be a shift in fat distribution. Women tend to accumulate more fat in the abdominal area, which is metabolically more active and produces substances that promote inflammation and insulin resistance.

  1. Glucose and Insulin Regulation:

Estrogen affects insulin sensitivity by influencing how cells respond to insulin. When estrogen levels are lower, cells may become less responsive to insulin, impairing glucose uptake and leading to higher blood sugar levels. This is particularly significant in muscle and liver cells, which are crucial in regulating glucose metabolism.

  1. Impact on Inflammatory Pathways:

Estrogen has anti-inflammatory properties and helps maintain a balanced inflammatory response in the body. When estrogen levels decrease, there may be an increase in pro-inflammatory markers, leading to chronic low-grade inflammation. This chronic inflammation can interfere with insulin signaling pathways, contributing to insulin resistance.

  1. Changes in Fat Metabolism:

Estrogen is involved in lipid metabolism, including the regulation of triglycerides and cholesterol levels. When estrogen levels are low, there may be alterations in lipid metabolism that can further promote insulin resistance and contribute to dyslipidemia (abnormal blood lipid levels).

  1. Role in Liver Function:

Estrogen plays a role in liver function and helps regulate glucose production and release by the liver. Lower estrogen levels can disrupt this balance and lead to increased glucose production, contributing to higher blood sugar levels and insulin resistance.

The Connection Between Menopause and Insulin Resistance:

Menopause, the natural process in a woman’s life when she stops menstruating, is characterized by a significant decline in estrogen production. It typically occurs in women around the age of 45 to 55, and during this transition, hormonal changes can impact insulin sensitivity.

As women approach menopause, their estrogen levels fluctuate, leading to increased insulin resistance and a higher risk of developing type 2 diabetes. Additionally, menopause is associated with other factors that can further worsen insulin resistance, such as changes in body composition, decreased physical activity, and weight gain.

Weight Gain and Insulin Resistance:

Weight gain is a common occurrence during menopause, and it can exacerbate insulin resistance. As women age, there is a natural decline in muscle mass, which reduces the body’s ability to burn calories efficiently. Combined with hormonal changes and decreased physical activity, this can lead to an increase in body fat, especially in the abdominal region.

Abdominal fat, known as visceral fat, is particularly metabolically active and releases various chemicals that contribute to inflammation and insulin resistance. As women gain more weight, especially around the abdomen, the risk of developing insulin resistance and other metabolic disorders rises significantly.

Managing Low Estrogen-Related Insulin Resistance:

While menopause and the subsequent decline in estrogen levels are natural processes, there are steps women can take to manage insulin resistance and support their overall health.

  1. Healthy Diet:

Adopting a balanced and nutritious diet can help stabilize blood sugar levels and manage insulin resistance. Focus on whole foods, including plenty of fruits, vegetables, whole grains, lean proteins, and healthy fats. Minimize the consumption of processed and sugary foods, as they can lead to rapid spikes in blood sugar levels.

  1. Regular Exercise:

Engaging in regular physical activity can improve insulin sensitivity and support weight management. Aim for a combination of cardiovascular exercises, strength training, and flexibility exercises to maintain muscle mass and overall health.

  1. Weight Management:

Maintaining a healthy weight through a balanced diet and regular exercise is crucial for managing insulin resistance. Losing even a small amount of weight can have a positive impact on insulin sensitivity.

  1. Stress Management:

Chronic stress can exacerbate insulin resistance. Incorporate stress-reducing activities such as meditation, yoga, deep breathing exercises, or spending time in nature to support overall well-being.

  1. Hormone Replacement Therapy (HRT):

For some women, hormone replacement therapy (HRT) may be a consideration to manage menopause symptoms and potentially improve insulin sensitivity. HRT should be discussed with a healthcare professional, as it comes with both benefits and risks.


Low estrogen levels, particularly during menopause, can lead to insulin resistance and other metabolic changes that impact women’s health. Understanding the connection between estrogen and insulin sensitivity can empower women to take proactive steps in managing their health during this stage of life.

By adopting a healthy lifestyle, including a balanced diet, regular exercise, stress management, and possibly hormone replacement therapy, women can mitigate the effects of low estrogen-related insulin resistance and support their overall well-being. As with any health concern, it’s essential to consult with a healthcare professional for personalized guidance and recommendations based on individual health needs.

Veronica Yoo

Veronica is dedicated and experienced nutritionist and certified health coach who specializes in functional medicine, She's a published author, nutritional instructor, WBFF professional figure athlete, and both the brains and beauty behind all that Makeover Nutrition offers.

Veronica is also the President & CEO of a BC based health and wellness association; Pacific Alliance of Body Care.