Written by Veronica Yoo

Protecting Against Oxidative Stress


In today’s fast-paced and stressful world, our bodies face numerous challenges that can negatively impact our health. One such challenge is oxidative stress, a condition that occurs when there is an imbalance between the production of harmful free radicals and the body’s ability to neutralize them. Oxidative stress has been linked to a wide range of health problems, including chronic diseases such as cancer, cardiovascular diseases, and neurodegenerative disorders. However, nature has provided us with a powerful ally in the fight against oxidative stress – selenium. In this blog post, we will explore the role of selenium in protecting against oxidative stress and its health benefits.

Understanding Oxidative Stress

To comprehend how selenium works as a protective agent, it is essential to grasp the concept of oxidative stress. Our bodies constantly generate reactive oxygen species (ROS) as a byproduct of various metabolic processes. While ROS play a role in normal physiological functions, excessive amounts can cause damage to cellular components, including DNA, proteins, and lipids. This damage is known as oxidative stress, and it contributes to the development and progression of various diseases.

Enter Selenium

Selenium is an essential trace mineral that is incorporated into proteins, forming selenoproteins, which play a crucial role in various physiological processes. One of the most well-known selenoproteins is glutathione peroxidase, an antioxidant enzyme that helps neutralize harmful ROS. By doing so, selenium helps to maintain the balance between free radicals and antioxidants, reducing the risk of oxidative stress.

  1. Selenium’s Antioxidant Properties:

As mentioned earlier, glutathione peroxidase is a selenoprotein that acts as an antioxidant. It plays a vital role in protecting cells from oxidative damage by neutralizing hydrogen peroxide and lipid peroxides. This process helps prevent oxidative stress-related damage to cellular components and reduces the risk of chronic diseases associated with oxidative stress.

  1. Selenium and the Immune System:

In addition to its antioxidant properties, selenium also plays a critical role in supporting a healthy immune system. Studies have shown that selenium deficiency can impair immune function, leading to increased susceptibility to infections and compromised immune responses. Selenium promotes the production of antibodies and enhances the activity of immune cells, thus bolstering the body’s defense mechanisms against harmful pathogens.

  1. Selenium and Cancer Prevention:

Cancer is a multifactorial disease influenced by genetic and environmental factors. Oxidative stress is known to contribute to the initiation and progression of cancer. Selenium’s antioxidant properties can help prevent DNA damage and inhibit the growth of cancer cells. Several studies have shown that adequate selenium intake is associated with a reduced risk of certain cancers, including prostate, colorectal, lung, and breast cancer.

  1. Selenium and Heart Health:

Cardiovascular diseases, including heart attacks and strokes, are leading causes of death worldwide. Oxidative stress plays a crucial role in the development and progression of these diseases. Selenium has been shown to have protective effects on the cardiovascular system by reducing oxidative stress, promoting vasodilation, and inhibiting the formation of blood clots. Additionally, selenium can help maintain normal cholesterol levels and reduce inflammation, further supporting heart health.

  1. Selenium and Brain Function:

The brain is highly susceptible to oxidative stress due to its high oxygen consumption and abundance of polyunsaturated fatty acids. Oxidative stress has been implicated in neurodegenerative disorders such as Alzheimer’s and Parkinson’s diseases. Selenium’s antioxidant properties and its role in preserving the integrity of cell membranes can help protect against neuronal damage and improve cognitive function.


In a world where oxidative stress is a pervasive threat to our health, selenium emerges as a powerful ally in combating this imbalance. As an essential trace mineral, selenium plays a critical role in protecting cells from oxidative damage, bolstering the immune system, and reducing the risk of chronic diseases such as cancer and cardiovascular disorders. By incorporating selenium-rich foods into our diets or through supplementation, we can harness the potential of this remarkable mineral to safeguard our well-being. Remember, a balanced and varied diet, coupled with a healthy lifestyle, is key to reaping the full benefits of selenium and maintaining optimal health in the face of oxidative stress.


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Veronica Yoo

Veronica is dedicated and experienced nutritionist and certified health coach who specializes in functional medicine, She's a published author, nutritional instructor, WBFF professional figure athlete, and both the brains and beauty behind all that Makeover Nutrition offers.

Veronica is also the President & CEO of a BC based health and wellness association; Pacific Alliance of Body Care.