Menopause’s Impact on Leptin and Ghrelin

Written by Veronica Yoo

Understanding the Relationship Between Menopause and Hormonal Fluctuations in Leptin and Ghrelin

Menopause marks a significant milestone in a woman’s life, a natural shift away from the reproductive years and into a new stage of life. However, this transition doesn’t come without its challenges. The complex web of hormonal changes that define menopause can lead to a range of physiological and psychological effects, including fluctuations in body weight and appetite. Two key players in this intricate dance are the hormones leptin and ghrelin, often referred to as the “hunger hormones”. These hormones play an instrumental role in regulating our appetite and metabolism, but their behavior can change dramatically during menopause. Understanding this relationship can shed light on some of the most common menopause-related complaints and open the door to more effective management strategies.

The Role of Leptin and Ghrelin in Normal Physiology

Before we delve into the impact of menopause on these hormones, it’s essential to understand their roles under normal physiological conditions.

Leptin is a hormone predominantly produced in the body’s adipose (fat) cells and enterocytes in the small intestine. As an energy-regulating hormone, leptin suppresses hunger and reduces fat storage in adipocytes. Its levels usually rise with increased fat mass, sending signals to the brain to decrease appetite, thereby helping maintain a balance in body weight.

On the flip side, ghrelin, primarily produced in the stomach, stimulates appetite, increases food intake, and promotes fat storage. Often referred to as the ‘hunger hormone’, ghrelin levels rise before meals, triggering feelings of hunger, and decrease after meals when satiety is achieved.

Together, leptin and ghrelin maintain the body’s energy balance, ensuring that we eat when we need to and stop when we’re full. However, this delicate balance can be disrupted during significant hormonal shifts, such as those experienced during menopause.

The Impact of Menopause on Hormone Levels

Menopause is characterized by a marked decrease in estrogen levels, the primary female sex hormone. This reduction can have wide-ranging impacts on a woman’s body, including influencing the behavior of leptin and ghrelin.

Estrogen is thought to enhance leptin sensitivity, making the body more responsive to its appetite-suppressing effects. Therefore, when estrogen levels drop during menopause, the body may become less sensitive to leptin. This reduced sensitivity could result in an increased appetite and, consequently, weight gain.

At the same time, the decline in estrogen levels during menopause can lead to an increase in ghrelin levels. Higher levels of ghrelin can further stimulate the appetite, making the double-whammy effect of reduced leptin sensitivity and increased ghrelin levels a potent recipe for weight gain and changes in body composition.

The Bigger Picture

However, the story doesn’t end with these hormonal changes. The menopausal transition is accompanied by various lifestyle and physiological changes that can further exacerbate the effects of fluctuating leptin and ghrelin levels.

For example, menopause is often associated with reduced physical activity and changes in sleep patterns, both of which can impact leptin and ghrelin levels. Stress, another common feature of the menopausal transition, can also increase ghrelin levels and stimulate appetite.

Additionally, the age-related decline in resting metabolic rate (the amount of energy your body uses at rest) can coincide with menopause, leading to an increased propensity to store fat. This phenomenon, coupled with the changes in leptin and ghrelin levels, can contribute to the weight gain often observed during menopause.

Navigating the Transition

Despite these challenges, understanding the relationship between menopause and the fluctuation in leptin and ghrelin levels can help inform strategies for maintaining a healthy weight and managing appetite during this transition.

Regular physical activity can help regulate leptin and ghrelin levels and counteract the age-related decline in metabolic rate. Similarly, maintaining a healthy diet, rich in protein and fiber, can help manage appetite and prevent overeating.

Furthermore, stress management techniques such as meditation, yoga, and other relaxation exercises can help mitigate the impact of stress on appetite and hormone levels. Finally, ensuring adequate sleep can also regulate leptin and ghrelin levels, helping maintain a healthy appetite and body weight.


The relationship between menopause and the fluctuation of leptin and ghrelin levels paints a complex picture of the many challenges women face during this transition. However, by understanding these changes, we can better equip ourselves to navigate this stage of life with grace and confidence.

Remember, everyone’s menopause experience is unique, and what works for one person might not work for another. If you’re struggling with weight gain or appetite control during menopause, consider seeking the advice of a healthcare provider or a nutritionist, who can provide personalized guidance based on your individual needs and circumstances. Menopause is a natural part of life – and with the right knowledge and support, it can also be a time of empowerment and positive change.

Veronica Yoo

Veronica is dedicated and experienced nutritionist and certified health coach who specializes in functional medicine, She's a published author, nutritional instructor, WBFF professional figure athlete, and both the brains and beauty behind all that Makeover Nutrition offers.

Veronica is also the President & CEO of a BC based health and wellness association; Pacific Alliance of Body Care.